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Updated on August 25, 2023
7 min read

What are the Effects of Mixing Latuda and Alcohol?

Alyssa Hill
Dr P. E. Pancoast, MD
Written by 
7 Sources Cited
Alyssa Hill
Written by 
7 Sources Cited

What is Latuda?

Latuda (Lurasidone hydrochloride) is a prescription drug for treating schizophrenia and bipolar disorder.1 Its desired effects include:

  • Enabling users to think clearly
  • Decreasing hallucinations
  • Improving appetite, sleep, and energy levels

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Latuda Prescription

Medical professionals often prescribe this medication orally, to be taken once daily with food. 

A specific dosage typically depends on the following:

  • Severity of symptoms
  • Age
  • Medical conditions
  • Lifestyle
  • Potential interaction with other medications

Healthcare providers prescribe Latuda for the following:

  • Adults and adolescents between 13 and 17 who have schizophrenia
  • Children and young adults older than 10 with bipolar disorder (or depressive conditions linked to bipolar I disorder)
  • Adults with bipolar depression concurrently taking lithium or valproate

Latuda Dosage and Intake

Latuda is generally available in the following doses:

  • 20 mg
  • 40 mg
  • 60 mg 
  • 80 mg
  • 120 mg

According to professional medical advice, Latuda should not be cut or crushed. 

Some people respond positively to Latuda within 1 to 3 weeks, while most see significant improvement by the 6th week.

Latuda Restrictions

You should not take Latuda if you have or are under the following circumstances:

  • Heart problems
  • Blood pressure problems
  • Other severe mood conditions
  • Diabetes
  • High cholesterol or triglycerides
  • High prolactin levels
  • Low white blood cell levels
  • Seizures
  • Kidney or liver problems
  • Parkinson’s disease 
  • Lewy body dementia
  • Pregnant or breastfeeding
  • Severe allergies

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Latuda and Alcohol Interaction

According to studies, alcohol is not known to interact with Latuda directly. However, it can worsen potential side effects, especially sleepiness.

Most alcohol and Latuda interactions remain unknown, so you must not drink alcohol when taking Latuda to prevent severe health consequences.

In addition, someone with an alcohol use disorder is less likely to take their prescription of Latuda as prescribed. Around 33% of people with schizophrenia struggle with alcohol use, furthering the risks associated with Latuda and possible interactions with alcohol.3

Other factors like supplements, food, and even lab tests can cause potential interactions with Latuda.

Can You Mix Alcohol and Latuda?

You should avoid drinking alcohol if prescribed Latuda. Alcohol often inhibits clarity when thinking, resulting in people making undesirable decisions. It rarely improves a person’s cognition and thinking abilities. 

Typical alcohol and Latuda interactions lead to drowsiness, confusion, and difficulty concentrating.2

If you partake in heavy alcohol use concurrent with mental health conditions, disclose this information to your doctor, who can prescribe an appropriate dose or recommend alternative treatments.

Potential Side Effects of Mixing Latuda and Alcohol

Because both Latuda and alcohol are central nervous system depressants, mixing them can cause or exacerbate the following side effects:

  • Drowsiness
  • Dizziness
  • Fatigue
  • Nausea and vomiting
  • Fall risks
  • Unintentional body movements (jerking)
  • Slow breathing
  • Sedation 
  • Psychomotor impairment
  • Increase respiratory and central nervous system (CNS) depression

Mixing alcohol with Latuda can also cause orthostatic hypotension or a shift in blood pressure when changing positions; these falls can potentially lead to injury. 

These side effects also make it especially dangerous for driving individuals, as excessive alcohol use impairs hand-eye coordination. 


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Alcohol Interactions with Other Bipolar Medications

Because bipolar disorder entails significant mood changes over short periods, someone with that diagnosis may feel inclined to drink alcohol to boost their mood.4 

An over-dependence on alcohol can eventually lead to alcohol abuse, making it difficult for someone with bipolar disorder to manage their symptoms.

Bipolar Disorder Prescription Medication

Common antipsychotic drugs prescribed to people with bipolar disorder include the following:

  • Mood stabilizers (Depakote, Lamictal, Lithium, Depakene)
  • Benzodiazepines and SSRI/SNRI antidepressants (Prozac/Zoloft, Zyprexa/Abilify, Sezone, Norpramin)
  • Anti-anxiety medication (Ativan, Restoril, Valium, Xanax)
  • Anticonvulsants (Tegretol)

When taken with benzodiazepines, Latuda can exacerbate side effects.5 Like alcohol, benzodiazepines are central nervous system depressants, which can slow breathing and lower blood pressure.

With antipsychotic medication taken alongside Latuda, certain drug interactions like sleepiness and involuntary movements are more common. 

Side Effects of Drinking Alcohol While on Bipolar Disorder Medication

People who drink alcohol while taking medications to treat bipolar disorder may experience adverse effects, such as the following:

  • Drowsiness and dizziness
  • Slowed breathing
  • Tremors
  • Respiratory depression
  • Increased risk of concurrent mental illness
  • Impaired motor control
  • Loss of effectiveness of medication
  • Increased risk of overdose
  • Convulsions and heart rhythm disturbances
  • Appetite loss
  • Upset stomach
  • Muscle and joint pain

What to Do if You've Consumed Alcohol While on Latuda

Mixing alcohol and Latuda can lead to severe consequences, and you should take immediate action. Here are some steps to consider:

Call Emergency Services

If you cannot reach the nearest hospital, dial 911 and request emergency services. Inform your healthcare provider so they can provide the appropriate guidance.

Don’t Induce Vomiting

While it may seem intuitive, you should avoid vomiting in case of additional complications.

Seek Help from a Neighbor or Family Member

If you struggle to stay awake, ask someone you trust for help. They can help you stay alert and responsive.

Don’t Wait for Symptoms 

Don’t wait for serious physical or mental warnings, even if your symptoms seem mild. Call your local emergency number immediately, especially if you experience suicidal thoughts. 

Common Questions on Latuda and Alcohol Use

Does alcohol make bipolar depression worse?

Alcohol can intensify bipolar depression because it leads to profound sedation.6 Alcohol intake can also significantly increase the occurrence of mania. 

Mania is a state of extreme mood elevation, often leading to risky behaviors like self-harm and other mental health problems.

People with bipolar disorder must take extra precautions, as alcohol addiction and depression typically concur.

Overall, consuming alcohol on Latuda and other antipsychotic drugs can cause destabilization, which can result in major depressive episodes.

How can you stay safe while taking Latuda?

You can stay safe when undergoing Latuda treatment by taking the following precautions:

Be Aware of Potential Drug Interactions When Consuming Alcohol

It’s best to avoid alcohol entirely when treating bipolar disorder.

Take Your Medication as Prescribed

When starting Latuda treatment, review your healthcare provider’s instructions. Do not modify your dosage unless explicitly instructed.

Disclose Other Medications You’re Taking

While over-the-counter medications like painkillers (ibuprofen) are safe to take with Latuda, you should disclose other medications you’re prescribed to your doctor in case of adverse drug effects.

Monitor Potential Side Effects

Pay attention to changes in mood, behavior, and physical symptoms, and relay any shifts to your doctor. Stop taking Latuda immediately if you experience an allergic reaction.

Consider Existing Medical Conditions

Inform your doctor about your health history, including movement disorders, high or low blood pressure, allergies, etc. Doctors typically advise against prescribing Latuda for older adults with dementia-related psychosis.

Take Precautions in Hot Weather

Latuda impacts the body’s ability to regulate temperature, so drink plenty of water.

Avoid Meals and Drinks That Contain Grapefruit

Grapefruit juice contains organic compounds that block the enzyme that breaks down Latuda and other drugs. When this enzyme becomes blocked, it can exacerbate the side effects associated with Latuda. 

Fruits that may cause other interactions include pomelo, lime, and Seville oranges.

Seek Help for Alcohol Addiction

If you tend to abuse substances or develop an alcohol dependency during treatment, seek professional help immediately.


While there is a need for more research regarding the potential drug interactions between alcohol and Latuda, it’s best to refrain from heavy alcohol use and take a holistic approach to recovery. 

Latuda is intended to help clarify thinking and improve a person’s grasp of reality, and alcohol typically does exactly the opposite. Drinking alcohol while taking Latuda will likely remove the beneficial effects of the medication through the common side effects of alcohol.

The best way to prevent interactions other than abstinence is to educate yourself regarding the potential consequences of taking Latuda while drinking alcohol and provide your doctor with a detailed medical history.

If you or someone you know struggles with alcohol use disorder, seek help from a medical professional.

Updated on August 25, 2023
7 sources cited
Updated on August 25, 2023
All Alcoholrehabhelp content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies.
  1. Tohen, M., and Nasrallah, H. “Bipolar depression: treatment with LATUDA monotherapy.” Current Psychiatry, 2015.
  2. Salloum, I., and Brown, E.S. “Management of comorbid bipolar disorder and substance use disorders.” The American Journal of Drug and Alcohol Abuse, 2017.
  3. Khokhar et al. “The link between schizophrenia and substance use disorder: A unifying hypothesis.” Schizophrenia Research, 2018.
  4. Meyer et al. “Do patients with bipolar disorder drink alcohol for different reasons when depressed, manic, or euthymic?” Journal of Affective Disorders, 2012.
  5. Uzun et al. “SIDE EFFECTS OF TREATMENT WITH BENZODIAZEPINES.” Psychiatria Danubina, 2010.
  6. Azorin et al. “Alcohol use and bipolar disorders: Risk factors associated with their co-occurrence and sequence of onsets.” Drug and Alcohol Dependence, 2017.
  7. Bailey et al. “Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?” Canadian Medical Association Journal, 2013.
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All content created by Alcohol Rehab Help is sourced from current scientific research and fact-checked by an addiction counseling expert. However, the information provided by Alcohol Rehab Help is not a substitute for professional treatment advice.
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